Chromatin Condensates

Mixing a bacterially expressed chromatin binding protein with a large piece of DNA results in
the formation of chromatin droplets that separate themselves from the surrounding liquid, like oil in a puddle.

If you look carefully, you can spot a merging event of 2 droplets from the above picture
The droplets flow and interact with themselves and their surroundings in very interesting ways.

It’s possible events such as these could happen on the microscale inside the nuclei of our cells, helping organize our genomes.

One Comment Add yours

  1. Manu Prakash says:

    What an elegant experiment! Just beautiful to watch the dynamics of these droplets under confinement. The fact that these are phase separated droplets of dna/chromatin instead of oil in water – it’s mind boggling. Absolutely beautiful.


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